Can colitis cause megaloblastic anemia?

Can colitis cause megaloblastic anemia?

Vitamin B12 and folate deficiency in IBD Vitamin B12 and folate deficiency are common in patients with IBD and may manifest as megaloblastic anaemia. The prevalence of vitamin B12 deficiency has been reported as 11%–24% and 7.5% in patients with Crohn’s disease and ulcerative colitis, respectively.

Can mesalamine cause bone marrow suppression?

Hematological complications of mesalazine are rare, but if bone marrow suppression is detected, immediate cessation of the drug and intensive immunosuppressive treatment with G-CSF should be considered.

How can megaloblastic anemia be prevented?

In the case of megaloblastic anemia caused by vitamin B12 deficiency, you may need monthly injections of vitamin B12. You may also be given oral supplements. Adding more foods with vitamin B12 to your diet can help.

Does ulcerative colitis cause pernicious anemia?

Pernicious anaemia is more common in people who already have autoimmune conditions such as Crohn’s disease and ulcerative colitis (both types of inflammatory bowel disease). B12 is absorbed in the end of the small intestine and people with Crohn’s disease in this area may not be able to absorb B12 very well.

How does megaloblastic Anaemia occur?

Vitamin deficiency resulting in megaloblastic anemia may result from inadequate intake of cobalamin and folate in the diet, poor absorption of these vitamins by the intestines or improper utilization of these vitamins by the body.

Can mesalamine cause anemia?

To the Editor: Aplastic anemia is a rare but documented side affect of mesalamine. Typically, occurring months to years after initial exposure, its diagnosis is difficult to make and is generally one of the exclusion. Most patients present with septic shock or with a complication of an infection.

Why is albumin low in ulcerative colitis?

Inflammatory activity of UC can lower albumin level by various mechanisms, such as malnutrition, malabsorption, greater fractional catabolic rate of albumin and increase transfer of albumin out of the vascular system.