What are the different methods of preparation of granules?
What are the different methods of preparation of granules?
What are the different methods of preparation of granules?
Granules are prepared by two methods – Dry or wet granulation. Dry granulation includes dry mixing, slug-de-slug and roller compaction processes. Wet granulation includes aqueous granulation and non-aqueous granulation. Dry granulation can be achieved through roller compaction or slugging.
What are the methods of dry granulation?
Methods of dry granulation
- Slugging technique.
- Roller compaction.
- Weighing formulation ingredients.
- Mixing of formulation ingredients.
- Compression of mixed powders into slugs.
- Milling and sieving of slugs.
- Mixing with disintegrant and lubricant.
- Compression of granules into tablets.
Why do we use dry granulation method?
The dry granulation process is used to form granules without using a liquid solution because the product granulated may be sensitive to moisture and heat. Forming granules without moisture requires compacting and densifying the powders. In this process the primary powder particles are aggregated under high pressure.
What is the purpose of granulation?
Granulation aims to provide a more homogenous mixture by formulation of granules that contain both the drug substance and the excipient particles. Hence, granulation can be thought of a process that aims to engineer the desired attributes of a particle and powder system.
What is slugging method?
Slugging is a pre-compression process for the formation of extra large tablets (slugs), usually of variable weight, due to poor flow of the drug powder. The resulting slugs are subsequently broken down into granules, which are recompressed to obtain the final tablets.
Why is wet granulation preferred?
Most pharmaceutical tablets are processed by wet granulation, and yet it is the most complex means of tablet processing. The popularity of wet granulation is because it can be applied to all drugs, and for many formulators it is the method of choice for drugs with a high dose and a very low dose.
Which drug is suitable for slugging?
Objective – Slugging is a pre-compression technique for the dry granulation of hydrolysable drugs (e.g. aspirin).
Which is better wet or dry granulation?
Wet granulation is used to prevent the degradation of active ingredients in the powder. The dry granulation process involves less equipment and space which are cost-effective. The wet granulation process involves more equipment and space which are more expensive than the dry granulation process.
What is the advantage of wet granulation?
1 Introduction
Wet granulation Advantages • More uniform mixing than dry granulation • More binding in less quantity of binder • Better content uniformity • Suitable for very low to very high drug content • Reduces sticking of blend to compression tooling What is FBD principle?
Fluid bed dryers work on the principle of fluidization, a process where a material is converted from a static solid-like state to a dynamic fluid-like state. In this process, hot gas or air is introduced through a perforated distribution plate into the area holding the material.
What is the new drug delivery system?
Drug delivery systems (DDSs) are developed to deliver the required amount of drugs effectively to appropriate target sites and to maintain the desired drug levels. Research in newer DDS is being carried out in liposomes, nanoparticles, niosomes, transdermal drug delivery, implants, microencapsulation, and polymers.
How often should I do slugging?
For best results, Dr. Que recommends using the slug life routine at night to ensure that your skin is as clean as possible before putting on your moisturizer. And Dr. Sisto says you can do it as frequently as every night if you wish.