Can Bence Jones protein be found in blood?

Can Bence Jones protein be found in blood?

The protein has also been linked to other types of cancer, such as lymphoma and Waldenstrom macroglobulinemia. Doctors may diagnose smouldering myeloma if they find Bence Jones protein but blood tests show normal blood counts, calcium levels, and kidney function.

Where does Bence Jones protein come from?

A small protein made by plasma cells (white blood cells that produce antibodies). It is found in the urine of most people with multiple myeloma (cancer that begins in plasma cells).

How do you collect urine for Bence Jones protein?

You give a sample of your urine in a pot to your doctor or nurse. The sample is sent to the laboratory for tests. Occasionally your doctor might need to collect your urine over a 24 hour period. You’ll need to take a container home to collect your urine.

Can Bence Jones protein in urine mean?

Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma. An abnormal result may also be due to: An abnormal buildup of proteins in tissues and organs (amyloidosis)

What does a positive Bence Jones test mean?

Bence Jones proteins are not normally found in urine, so a positive test indicates that you probably have multiple myeloma. Other kinds of cancer may also be associated with a positive result. An abnormal test may indicate other types of cancer including lymphoma, chronic lymphocytic leukemia, and macroglobulinemia.

What is the unique characteristic of Bence Jones protein?

A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22–24 kDa. Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström’s macroglobulinemia.

How long does it take to get Bence Jones test results?

It can take anywhere from a few days to two weeks to get your results, depending on the lab and your doctor. Bence Jones proteins are not normally found in urine, so a positive test indicates that you probably have multiple myeloma. Other kinds of cancer may also be associated with a positive result.

What is the clinical significance of Bence Jones protein?

The Bence-Jones protein urine test is used most often to diagnose and check on multiple myeloma, a type of cancer. Or an abnormal Bence-Jones test result may mean you have a type of malignant lymphoma. These are cancers of the lymphatic system. Multiple myeloma is a type of blood cancer that affects plasma cells.

Where does Bence Jones protein come from in urine?

These excess free light chains proteins are released into the bloodstream and since they are relatively small molecules, they are filtered by the kidneys and released into the urine. Another term for these excess free light chains of immunoglobulins (kappa κ or lambda λ) in the urine of multiple myeloma patient which is called Bence-Jones protein.

What kind of test is used to detect Bence Jones proteinuria?

Detection of Bence-Jones proteinuria requires sophisticated tests such as urine protein electrophoresis, immunoelectrophoresis, and immunofixation electrophoresis. The screening test most commonly used is urine protein electrophoresis.

How does the body get rid of Bence Jones protein?

One part of the paraprotein is the light chain or Bence Jones protein, which the body gets rid of in the urine. Many people with myeloma have Bence Jones protein in their urine. These protein molecules can damage the kidneys as they pass through them from the blood to the urine. You give a sample of your urine in a pot to your doctor or nurse.

Where are Bence Jones proteins found in multiple myeloma?

Multiple myeloma is a clonal proliferation of malignant plasma cells, typically arising in the bone marrow, that produce an immunoglobulin or component of immunoglobulin. Because of their small size (MW=22,000-44,000), Bence-Jones proteins can readily pass from the blood through the normal glomerular fenestrations of the kidney into the urine.

What causes Bence Jones protein in urine test?

The Bence Jones protein urine test is one of many tests that doctors can do if they suspect that someone has multiple myeloma, which is a form of blood cancer. Healthy urine does not contain Bence Jones protein, so its presence is an indication of a health problem.

What do you need to know about Bence Jones protein?

Healthy urine does not contain Bence Jones protein, so its presence is an indication of a health problem. Other names for this test include urine protein electrophoresis (UPEP), urine immunofixation electrophoresis, or immunoassay for free light chains. Why is it used?

What kind of cancer can a Bence Jones urine test show?

A Bence Jones protein urine test is one of several tests used to diagnose a type of blood cancer known as multiple myeloma. Between 50 and 80 percent of people with multiple myeloma will have Bence Jones protein in their urine. It is also linked to cancers of the lymphatic system.

Multiple myeloma is a clonal proliferation of malignant plasma cells, typically arising in the bone marrow, that produce an immunoglobulin or component of immunoglobulin. Because of their small size (MW=22,000-44,000), Bence-Jones proteins can readily pass from the blood through the normal glomerular fenestrations of the kidney into the urine.