What causes SMS syndrome?

What causes SMS syndrome?

Smith-Magenis Syndrome (SMS) is a rare neurobehavioral disorder characterized by a recognizable pattern of physical, behavioral, and developmental features. It is caused by particular genetic changes on chromosomal region 17p11. 2, which contains the gene RAI1.

Are you born with Smith-Magenis syndrome?

Smith-Magenis syndrome (SMS) is a complex developmental disorder that affects multiple organ systems of the body. The disorder is characterized by a pattern of abnormalities that are present at birth (congenital) as well as behavioral and cognitive problems.

Can people with SMS have kids?

Most often, people with Smith-Magenis syndrome have no history of the condition in their family and go to have other children without a genetic abnormality after a child with SMS.

Which hormone is commonly secreted abnormally in people with Smith-Magenis syndrome?

Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome.

How common is SMS?

How common is SMS? Although the exact incidence is not known, it is estimated that SMS occurs in between 1 out of every 15,000 and 25,000 births. SMS is vastly under-diagnosed, but as the awareness of it increases, the number of people identified grows every year.

Is Smith-Magenis syndrome a learning disability?

Smith-Magenis Syndrome (SMS) is a developmental disorder that affects many parts of the body. The major features of this condition include mild to severe learning disability, distinctive facial features, sleep disturbances, and behavioral problems. Smith-Magenis syndrome affects an estimated 1 in 25,000 individuals.

How many people in the world have Smith-Magenis syndrome?

Smith-Magenis syndrome affects at least 1 in 25,000 individuals worldwide. However, researchers believe that many people with this condition are not diagnosed, so the true prevalence may be closer to 1 in 15,000 individuals.

Is Smith-Magenis syndrome Rare?

How common is Smith-Magenis Syndrome?

Why you should stop using SMS?

SMS attacks either compromise phones/phone numbers or the messaging centers themselves within mobile networks. These messages are in plain text form—they’re not encrypted between sender and receiver, so if an attacker can access the message, they can read the content.

Can a person with Smith Magenis syndrome be inherited?

SMS is typically not inherited. This condition usually results from a genetic change that occurs during the formation of reproductive cells (eggs or sperm) or in early fetal development. People with Smith-Magenis syndrome most often have no history of the condition in their family.

Where does the deletion occur in Smith Magenis syndrome?

Most people with Smith-Magenis syndrome (SMS) have a deletion of genetic material from a specific region of chromosome 17. The deletion is not usually inherited, occurring randomly during the formation of egg or sperm cells in a parent, or in early embryonic development.

How is the RAI1 gene affected by Smith Magenis syndrome?

It is unclear how a loss of one copy of the RAI1 gene leads to the other physical, mental, and behavioral problems associated with this condition. A small percentage of people with Smith-Magenis syndrome have a mutation in the RAI1 gene instead of a chromosomal deletion.

What are the facial features of Smith Magenis syndrome?

Some affected infants may have an abnormally small jaw (micrognathia) and the facial appearance is more “cherubic” with rosy cheeks. As affected individuals age, micrognathia may change so that the lower jaw abnormally protrudes outward (relative prognathia). In general, the distinctive facial features associated with SMS progress with age.

What is the genetic cause of Smith Magenis syndrome?

Smith-Magenis Syndrome. Smith-Magenis Syndrome (SMS) is a rare neurobehavioral disorder characterized by a recognizable pattern of physical, behavioral, and developmental features. It is caused by particular genetic changes on chromosomal region 17p11.2, which contains the gene RAI1.

Most people with Smith-Magenis syndrome (SMS) have a deletion of genetic material from a specific region of chromosome 17. The deletion is not usually inherited, occurring randomly during the formation of egg or sperm cells in a parent, or in early embryonic development.

What happens to eyes with Smith Magenis syndrome?

Affected individuals may have eye abnormalities that cause nearsightedness ( myopia ), strabismus, and other problems with vision. Heart and kidney defects also have been reported in people with Smith–Magenis syndrome, though they are less common.

What kind of Doctor treats Smith Magenis syndrome?

Treatment of Smith-Magenis syndrome is complex and requires a multidisciplinary team including, among others, geneticists, psychiatrists, neuropediatricians/neurologists, somnologists, developmental and behavioral pediatricians, and speech and language therapists.